KMT2A::MLLT1 / KMT2A::ELL t(11;19)
Quantitative RQ-PCR detection of KMT2A::MLLT1 (MLL::ENL) and KMT2A::ELL (MLL::ELL) fusion transcripts from t(11;19) in ALL and AML.
NPM1 Mutation Analysis
PCR fragment analysis of common 4 bp insertion mutations in NPM1 exon 12 for AML diagnosis.
NUP98::KDM5A t(11;12)
Quantitative RQ-PCR detection of NUP98::KDM5A fusion transcripts from the t(11;12)(p15;p13) translocation.
NUP98::NSD1 t(5;11)
Quantitative RQ-PCR detection of NUP98::NSD1 fusion transcripts from the cryptic t(5;11) translocation.
PML::RARA t(15;17)
Multiplex RQ-PCR detection of PML::RARA fusion transcripts (long, variant, short isoforms) for acute promyelocytic leukemia diagnosis and monitoring. STAT testing available.
RBM15::MRTFA t(1;22)
Quantitative RQ-PCR detection of RBM15::MRTFA (MKL1) fusion transcripts from the t(1;22) translocation.
RUNX1::RUNX1T1 (AML1-ETO) t(8;21)
Quantitative RQ-PCR detection of RUNX1::RUNX1T1 (AML1::ETO) fusion from t(8;21), associated with favorable prognosis in AML.
JAK2 V617F Mutation Analysis
Allele-specific PCR detection of the JAK2 V617F mutation for myeloproliferative neoplasm diagnosis and monitoring.
STAT3 Mutation Analysis
Sanger sequencing of STAT3 exons 19, 20, and 21 mutations for T-LGL leukemia diagnosis. Cell sorting available for increased sensitivity.
KAT6A::CREBBP t(8;16)
Quantitative RQ-PCR detection of the KAT6A::CREBBP fusion from t(8;16)(p11;p13) translocation in a subset of AML patients.