Fluorescence In Situ Hybridization (FISH)

Update on Paraffin FISH Samples:

  • Submit slide mounted paraffin sections only (marked H&E,  5 to 8 paraffin sections cut at 4 microns)
  • New TAT will be 3-7 days

 

All Lymphoma probe panels are also available for paraffin-embedded specimens.  For other FISH probe sets, please inquire with the laboratory.

Plasma cell enrichment performed on all MM/MGUS specimens.

FISH Probes / Panels by Disease Application

 

FISH Panels
Panel Probes Validated for use in Paraffin
AML Panel AML1/ETO (RUNX1T1/RUNX1), PML/RARA, CBFB, MLL, Del(7q),  Del(20q) + D8Z2
AML Supplemental Panel BCR/ABL1, EVI1, DEK/NUP214, NUP98
T-Cell Lymphoma ALK, TCRAD, MYB/D6Z1, TCRB
B-Cell Lymphoma Panel BCL6, MALT, BCL1 (CCND1), IGH/BCL2
x
Burkitt’s Lymphoma Panel MYC/IGH, MYC
x
Double/Triple Hit Lymphoma MYC, MYC/IGH, IGH/BCL2, BCL6
x
CML Panel BCR/ABL1
CLL Panel with BCL1 D13S319/13q34, D12Z3, ATM, TP53,MYB, CCND1/IGH
CLL Panel without BCL1 D13S319/13q34, D12Z3, ATM,TP53
MDS Panel Del(5q)(EGFR1), Del(7q), Del(20q)+D8Z2, TP53/D17Z1
*MM/MGUS Panel TP53/D17Z1, FGFR3/IGH, D13S319/13q34, CCND1/IGH, Cen3/Cen15, CDKN2C/CKS1B(1p/1q)
*reflexive probes for IGH gain IGH-breakapart, IGH/CCND1, IGH/MAF, IGH/CCND3, IGH/MAFB, IGH/MYC
MPN/Eosinophilia PDGFRA, PDGFRB, FGFR1, JAK2, BCR/ABL1
Standard ALL Panel BCR/ABL1, cMYC/IGH, TEL/AML1(ETV6/RUNX1), MLL(KMT2A), ABL1, ABL2
BCR-ABL1 (Ph)-like ALL CRLF2,  JAK2, IGH, EPOR,
ALL Panel Pediatric Add On  Cen4/Cen10, PBX1/TCF3, PDGFRB, p16/D9Z3
T-ALL BCR/ABL1, MLLT3/MLL, TCRB, TCRAD, p16/D9Z3, cMYC

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