KMT2A::MLLT11 (MLL::AF1) t(1;11)
Quantitative RQ-PCR detection of KMT2A::MLLT11 fusion transcripts from the t(1;11) translocation.
CXCR4 Mutation Analysis
Sanger sequencing of CXCR4 c-terminal mutations associated with ibrutinib resistance in Waldenström's macroglobulinemia.
DEK::NUP214 t(6;9)
Quantitative RQ-PCR detection and monitoring of the t(6;9)(p22;q34) DEK::NUP214 fusion transcript in AML.
ETV6::RUNX1 t(12;21)
Quantitative RQ-PCR detection of the t(12;21) ETV6::RUNX1 (TEL::AML1) fusion, associated with favorable prognosis in ALL.
FIP1L1::PDGFRA del(4q12)
Quantitative RQ-PCR detection of the FIP1L1::PDGFRA fusion from interstitial 4q12 deletion in HES and chronic eosinophilic leukemia.
FLT3 ITD/TKD Mutation Analysis
PCR fragment analysis with EcoRV digest detecting FLT3 internal tandem duplications (ITD) and D835 tyrosine kinase domain mutations in AML.
IDH1 Mutation Analysis
Sanger sequencing of IDH1 exon 4 mutations including R132 to inform IDH inhibitor treatment decisions.
IDH2 Mutation Analysis
Sanger sequencing of IDH2 exon 4 mutations at codons R140 and R172 to inform IDH inhibitor treatment decisions.
IGHV Somatic Hypermutation Analysis
NGS deep sequencing of IGHV to determine somatic hypermutation status, an independent prognostic marker in CLL.
B-Cell IGH Gene Rearrangement
PCR fragment-length analysis detecting clonal IGH rearrangements (FR1, FR2, FR3) for B-cell lymphoma diagnosis and monitoring.