IGHV Somatic Hypermutation Analysis
NGS deep sequencing of IGHV to determine somatic hypermutation status, an independent prognostic marker in CLL.
B-Cell IGK Gene Rearrangement
PCR fragment-length analysis of clonal IGK rearrangements for B-cell lymphoma diagnosis and minimal residual disease monitoring.
JAK2 Exon 12 Mutation Analysis
PCR fragment analysis of JAK2 exon 12 insertion/deletion and K539L mutations for myeloproliferative neoplasm diagnosis.
BCR::ABL1 Qualitative Breakpoints p190 vs p210
Qualitative RQ-PCR identification of BCR::ABL1 fusion transcript breakpoint type (major p210 vs minor p190) for diagnosis of CML, ALL, and AML.
BRAF V600E Mutation Analysis
Sanger sequencing detection of the BRAF V600E mutation for hairy cell leukemia diagnosis and monitoring.
CALR Mutation Analysis
PCR fragment-length analysis of CALR exon 9 insertion/deletion mutations for myeloproliferative neoplasm diagnosis and monitoring.
CBFA2T3::GLIS2
Quantitative RQ-PCR detection and monitoring of the inv(16)(p13.3q24.3) CBFA2T3::GLIS2 fusion in AML with RAM immunophenotype.
CBFB::MYH11 inv(16) or t(16;16)
Quantitative RQ-PCR detection and monitoring of CBFB::MYH11 fusion transcripts (types A, D, E) from inv(16)/t(16;16) in AML.
CD33 SNP Genotyping
Allele-specific PCR genotyping of the CD33 rs12459419 SNP, associated with CD33 antigen expression and gemtuzumab response.
CEBPa bZIP Mutation Analysis
PCR fragment-length analysis of duplications/deletions in the CEBPA bZIP domain for AML diagnosis and monitoring.