FIP1L1::PDGFRA del(4q12)
Quantitative RT-PCR detection of the FIP1L1::PDGFRA fusion from interstitial 4q12 deletion in HES and chronic eosinophilic leukemia.
IGHV Somatic Hypermutation Analysis
Sanger sequencing of IGHV to determine somatic hypermutation status, an independent prognostic marker in CLL.
KMT2A::AFF1 t(4;11) (aka MLL::AF4)
Quantitative RT-PCR detection of KMT2A::AFF1 fusion transcripts from t(4;11), associated with poor prognosis in B-ALL.
DEK::NUP214 t(6;9)
Quantitative RT-PCR detection and monitoring of the t(6;9)(p22;q34) DEK::NUP214 fusion transcript in AML.
IDH2 Mutation Analysis
Sanger sequencing of IDH2 exon 4 mutations at codons R140 and R172 to inform IDH inhibitor treatment decisions.
T-Cell Receptor Beta Gene Rearrangement (TCRB)
PCR fragment analysis detecting clonal T-cell receptor beta rearrangements for T-cell malignancy diagnosis and monitoring. May be ordered concurrently with TCRG or as reflex.
MYD88 L265P Mutation Analysis
Cell sorting and Sanger sequencing detection of MYD88 L265P mutation in lymphoplasmacytic lymphoma and Waldenström's macroglobulinemia.
ETV6::RUNX1 t(12;21)
Quantitative RT-PCR detection of the t(12;21) ETV6::RUNX1 (TEL::AML1) fusion, associated with favorable prognosis in ALL.
FLT3 ITD/TKD Mutation Analysis
PCR fragment analysis with EcoRV digest detecting FLT3 internal tandem duplications (ITD) and D835 tyrosine kinase domain mutations in AML.
NUP98::KDM5A t(11;12)
Quantitative RT-PCR detection of NUP98::KDM5A fusion transcripts from the t(11;12)(p15;p13) translocation.
