JAK2 V617F Mutation Analysis
Allele-specific PCR detection of the JAK2 V617F mutation for myeloproliferative neoplasm diagnosis and monitoring.
STAT3 Mutation Analysis
Sanger sequencing of STAT3 exons 19, 20, and 21 mutations for T-LGL leukemia diagnosis. Cell sorting available for increased sensitivity.
CALR Mutation Analysis
PCR fragment-length analysis of CALR exon 9 insertion/deletion mutations for myeloproliferative neoplasm diagnosis and monitoring.
BCR::ABL1 IS t(9;22)
Quantitative RT-PCR detection and monitoring of the t(9;22) BCR::ABL1 fusion transcript (p210 and p190) for CML, ALL, and AML diagnosis and MRD.
BCR::ABL1 Qualitative Breakpoints p190 vs p210
Qualitative RT-PCR identification of BCR::ABL1 fusion transcript breakpoint type (major p210 vs minor p190) for diagnosis of CML, ALL, and AML.
ABL1 Tyrosine Kinase Domain Mutation Analysis
Sanger sequencing of ABL1 tyrosine kinase domain to detect imatinib resistance mutations in BCR::ABL1-positive CML, ALL, and AML.
KMT2A::MLLT11 (MLL::AF1) t(1;11)
Quantitative RT-PCR detection of KMT2A::MLLT11 fusion transcripts from the t(1;11) translocation.
CBFB::MYH11 inv(16) or t(16;16)
Quantitative RT-PCR detection and monitoring of CBFB::MYH11 fusion transcripts (types A, D, E) from inv(16)/t(16;16) in AML.
CD33 SNP Genotyping
Sanger sequencing genotyping of the CD33 rs12459419 SNP, associated with CD33 antigen expression and gemtuzumab response.
CBFA2T3::GLIS2
Quantitative RT-PCR detection and monitoring of the inv(16)(p13.3q24.3) CBFA2T3::GLIS2 fusion in AML with RAM immunophenotype.
