BRAF V600E Mutation Analysis
Sanger sequencing detection of the BRAF V600E mutation for hairy cell leukemia diagnosis and monitoring.
STAT3 Mutation Analysis
Sanger sequencing of STAT3 exons 19, 20, and 21 mutations for T-LGL leukemia diagnosis. Cell sorting available for increased sensitivity.
ABL1 Tyrosine Kinase Domain Mutation Analysis
Sanger sequencing of ABL1 tyrosine kinase domain to detect imatinib resistance mutations in BCR::ABL1-positive CML, ALL, and AML.
CD33 SNP Genotyping
Sanger sequencing genotyping of the CD33 rs12459419 SNP, associated with CD33 antigen expression and gemtuzumab response.
CXCR4 Mutation Analysis
Sanger sequencing of CXCR4 c-terminal mutations associated with ibrutinib resistance in Waldenström's macroglobulinemia.
IDH1 Mutation Analysis
Sanger sequencing of IDH1 exon 4 mutations including R132 to inform IDH inhibitor treatment decisions.
IGHV Somatic Hypermutation Analysis
Sanger sequencing of IGHV to determine somatic hypermutation status, an independent prognostic marker in CLL.
IDH2 Mutation Analysis
Sanger sequencing of IDH2 exon 4 mutations at codons R140 and R172 to inform IDH inhibitor treatment decisions.
