KMT2A::AFF1 t(4;11) (aka MLL::AF4)
Quantitative RQ-PCR detection of KMT2A::AFF1 fusion transcripts from t(4;11), associated with poor prognosis in B-ALL.
RUNX1::RUNX1T1 (AML1-ETO) t(8;21)
Quantitative RQ-PCR detection of RUNX1::RUNX1T1 (AML1::ETO) fusion from t(8;21), associated with favorable prognosis in AML.
ETV6::RUNX1 t(12;21)
Quantitative RQ-PCR detection of the t(12;21) ETV6::RUNX1 (TEL::AML1) fusion, associated with favorable prognosis in ALL.
IGHV Somatic Hypermutation Analysis
NGS deep sequencing of IGHV to determine somatic hypermutation status, an independent prognostic marker in CLL.