Molecular Diagnostic Test Menu

Turn-Around-Time: 24 – 48 hrs Unless Otherwise Specified

* RNA-based assays = please provide minimum of 5 mL peripheral blood or 3 mL of bone marrow in lavender top tube [EDTA]. Overnight shipping and processing within 24 hours is required for accurate results.

+DNA-based assays = Fresh or paraffin-embedded specimens. FFPE bone marrow biopsies can result in inadequate DNA due to decalcification treatment [clot sections preferable].

Test Clinical Application Methodology CPT Codes
B-cell Gene Rearrangement (IgH)+ Monoclonality detection and confirmation in B-cell malignancies. Monoclonality profiling for disease monitoring. PCR 81261
B-cell Gene Rearrangement (IgK)+ For 10 % of B-cell malignancies not detected by IgH assay (germinal and post-germinal center with somatic hypermutations). PCR 81264
T-cell (Gamma) Gene Rearrangement+ Monoclonality detection and confirmation in T-cell malignancies. Monoclonality profiling for disease monitoring. PCR 81342
T-cell (Beta) Gene Rearrangement+ For >10% of T-cell malignancies not detected by TCRG (Gamma) gene rearrangement analyis. PCR 81340
IGHV Mutation Analysis*

TAT:3-7 days

Determines mutation status of rearranged immunoglobulin heavy chain variable (IGHV) genes in patients with chronic lymphocytic leukemia (CLL) as well as a prognosticator in hairy cell leukemia. Sanger Sequencing 81263
ABL Sequence Analysis*

TAT:3-7 days

Analyzes the patient-specific BCR/ABL fusion transcript sequence for the presence of Gleevec resistance mutations in ABL kinase domain. Sanger Sequencing 81403
BCL-1 t(11;14)+ Quantitative monitoring of t(11;14) for Mantle Cell Lymphoma. Real-Time Quantitative PCR 81168
BCL-2 t(14;18)+ Quantitative monitoring of t(14;18) for Follicular Lymphoma. Real-Time Quantitative PCR 81278
ALL Panel * Detection of BCR-ABL, E2A-PBX1, MLL-AF4 and TEL-AML1 Real-Time Quantitative PCR 81206, 81207
E2A-PBX1 t(1;19)* Minimal residual disease (MRD) detection of t(1;19) for ALL. Real-Time Quantitative PCR 81401
MLL-AF4 t(4;11) * MRD detection of t(4;11) and prognostic indicator for ALL. Real-Time Quantitative PCR 81401
TEL-AML1 t(12;21) * MRD detection of t(12;21)and prognostic indicator for ALL. Real-Time Quantitative PCR 81401
BCR-ABL IS t(9;22) * Detection and quantitative monitoring [International Scale] of t(9;22) for CML and ALL.