FISH Probes / Panels by Disease Application

Update on Paraffin FISH Samples:

  • Submit slide mounted paraffin sections only (marked H&E, 5 to 8 paraffin sections cut at 4 microns).
  • New TAT will be 3-7 days.

All Lymphoma probe panels are also available for paraffin-embedded specimens. For other FISH probe sets, please inquire with the laboratory.

Plasma cell enrichment performed on all MM/MGUS specimens.

FISH Panels
Panel Probes Validated for use in Paraffin
B-ALL, BCR-ABL1 -like(Ph-like) Panel CRLF2, JAK2, IGH, EPOR  
B-ALL Panel (Adult) BCR/ABL1, MYC/IGH, TEL/AML1(ETV6/RUNX1), MLL(KMT2A), ABL1, ABL2  
B-ALL Panel (Pediatric) BCR/ABL1, MYC/IGH, TEL/AML1(ETV6/RUNX1), MLL(KNT2A), ABL1, ABL2, Cen4/Cen10, PBX1/TCF3, PDGFRB, TP16(CDKN2A)/D9Z3  
AML Panel (Pediatric) AML1/ETO (RUNX1T1/RUNX1), PML/RARA, CBFB, MLL, Del(7q), EV1(MECOM), NUP98 (11p15), DEK/NUP214  
AML Supplemental Panel BCR/ABL1, EVI1, DEK/NUP214, NUP98  
AML Panel (Adult) AML1/ETO (RUNX1T1/RUNX1), PML/RARA, CBFB, MLL, Del(7q), Del(20q), + D8Z2  
T-cell Lymphoma ALK, TCRAD (for TRA & TRD), MYB/D6Z1, TCRB (for TRB)  
B-cell Lymphoma Panel (NHL Panel) BCL6, MALT, BCL1 (CCND1), IGH/BCL2
x
Burkitt’s Lymphoma Panel MYC/IGH, MYC
x
Double/Triple Hit Lymphoma (DHL Panel) MYC, MYC/IGH, IGH/BCL2, BCL6
x
CML Panel BCR/ABL1  
CLL Panel with BCL1 (CCND1) D13S319/13q34, D12Z3, ATM, TP53,MYB, CCND1/IGH  
CLL Panel without BCL1 (without CCND1) D13S319/13q34, D12Z3, ATM,TP53  
MDS Panel Del(5q)(EGFR1), Del(7q), Del(20q)+D8Z2, TP53/D17Z1  
MM/MGUS Panel TP53/D17Z1, FGFR3/IGH, D13S319/13q34, CCND1/IGH, Cen3/Cen15, CDKN2C/CKS1B(1p/1q)  
MM Panel reflexive probes for IGH